Age-related decline in actomyosin structure and function
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چکیده
منابع مشابه
Age-related decline in actomyosin structure and function.
This review focuses on the role of changes in the contractile proteins actin and myosin in age-related deterioration of skeletal muscle function. Functional and structural changes in contractile proteins have been determined indirectly from specific force and unloaded shortening velocity of permeabilized muscle fibers, and were detected directly from site-directed spectroscopy in muscle fibers ...
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To understand the molecular basis of the functional decline in aging muscle, we examined the functional (actomyosin ATPase) and chemical (cysteine content) changes in actin and myosin purified from the muscles of young (4- to 12-month-old) and old (27- to 35-month-old) Fisher 344 rats. Using the soluble, catalytically active myosin fragment, heavy meromyosin (HMM), we determined the maximum rat...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2007
ISSN: 0531-5565
DOI: 10.1016/j.exger.2007.06.015